BALTIMORE — Soldiers haunted by scenes of war and victims scarred by violence often wish they could wipe the memories from their minds. Researchers at the Johns Hopkins University are working to make that wish come true.
A commercial drug remains far off - and its use would be subject to many ethical and practical questions. But scientists have laid a foundation with their discovery that proteins can be removed from the brain’s fear center to erase memories forever.
“When a traumatic event occurs, it creates a fearful memory that can last a lifetime and have a debilitating effect on a person’s life,” says Richard Huganir, professor and chairman of neuroscience in the Hopkins School of Medicine. He said his finding on the molecular process “raises the possibility of manipulating those mechanisms with drugs to enhance behavioral therapyfor such conditions as posttraumatic stress disorder.”
The research has drawn interest from some involved in mental health care, and some concern.
Kate Farinholt, executive director of the mental health support and information group National Alliance on Mental Illness (NAMI) Maryland, said many people suffering from a traumatic event might benefit from erasing a memory. But there are a lot of unanswered questions, she said.
“Erasing a memory and then everything bad built on that is an amazing idea, and I can see all sorts of potential,” she said. “But completely deleting a memory, assuming it’s one memory, is a little scary.How do you remove a memory without removing a whole part of someone’s life, and is it best to do that, considering that people grow and learn from their experiences.”
Past research already had shown that a specific form of behavior therapy seemed to erase painful memories. But relapse was possible because the memory wasn’t necessarily gone.
By looking at that process, Huganir and postdoctoral fellow Roger Clem discovered a “window of vulnerability” when unique receptor proteins are created. The proteins mediate signals traveling within the brain as painful memories are made. Because the proteins are unstable, they can be easily removed with drugs or behavior therapy during the window, ensuring the memory is eliminated.
Researchers used mice to find the window but believe that the process would be the same in humans. They conditioned the rodents with electric shocks to fear a tone. The sound triggered creation of the proteins, called calciumpermeable AMPA receptors, which formed for a day or two in the fear center, or amygdala, of the mice’s brains.
The researchers are working on ways to reopen the window down the road by recalling the painful memory and to use medication to eliminate the protein. That’s important because doctors often don’t see victims immediately after a traumatic event. Post-traumatic stress disorder, for example, can surface months later.
Huganir, whose report on erasing fear memories in rodents was published online in October by Science Express,also believes that the window may exist in other centers of learning and may eventually be used to treat pain or drug addiction.
Connie Walker, a Leonardtown, Md., mother of an Iraq war veteran suffering from post-traumatic stress disorder, said there isn’t enough attention given to the injuries of servicemen in general and she specifically supports research into post-traumatic-stress-related therapy. But Walker, a 23-year Navy veteran herself, said she wouldn’t want her son to take a medication to erase what he witnessed.
She said her son began functioning well after he got therapy, which she said should be more readily available to every wounded veteran.
“My gut reaction to a drug that erases memories forever is to be frightened,” she said. “A person’s memory is very much a part of who they are. I recognize we all have some bad memories, though I doubt they can compete with what’s coming back from Iraq and Afghanistan. But how can a drug like that be controlled? What else gets eliminated accidentally?”
There aren’t yet drugs to erase memories. But there are medications also targeting the amygdala and used with behavior therapy that can lessen the emotional response to painful memories in those with posttraumatic stress disorder, such as propranolol, a beta blocker commonly used to treat hypertension.
Paul Root Wolpe, director of the Center for Ethics at Emory University in Atlanta, says permanently erasing memories in humans, if it can be done, wouldn’t be a lot different ethically than behavior modification. Both are memory manipulation. But, he said, erasing memories is fraught with many more potential pitfalls.
He also said that post-traumatic stress disorder sufferers, such as servicemen in Iraq and Afghanistan, frequently experience more than one traumatic event, and trying to eliminate all the memories could significantly alter a person’s personality and history.
Wolpe said it can be called dementia when someone forgets that much of their past.
“I don’t know what it means to erase that much of a person’s life,” he said. “You’d leave a giant hole in a person’s history. I tend to doubt you’d even be able to.”
Front Section, Pages 2 on 11/28/2010