PHILADELPHIA -- Tom Brady threw two touchdown passes, Leonard Fournette ran for two scores and the Tampa Bay Buccaneers beat the Philadelphia Eagles 28-22 on Thursday night.
The defending Super Bowl champion Buccaneers (5-1) lost another cornerback when three-time All-Pro Richard Sherman left in the first quarter with a hamstring injury but their depleted defense held on after Jalen Hurts rallied the Eagles from a 28-7 deficit.
Playing with an injured thumb, Brady came out firing. The 44-year-old, seven-time Super Bowl champion tossed TD passes on Tampa Bay's first two drives while going 11 for 12 for 121 yards.
His best play came after Hurts' second TD run and a two-point conversion pulled Philadelphia within six points with 3:05 left in the fourth quarter.
Facing a third-and-7 from Philadelphia's 45, Brady rolled away from pressure and threw a perfect pass to Antonio Brown for a 27-yard gain to extend the drive and the Bucs ran out the clock.
Brady finished 34 of 42 for 297 yards and an interception.
The Eagles (2-4) are winless in three home games under rookie Coach Nick Sirianni. They heard boos at halftime but fought back to make it close.
Brady's 2-yard TD pass to O.J. Howard gave the Buccaneers a 7-0 lead. The Eagles answered on Hurts' 5-yard scoring pass to Zach Ertz. Brady then hit Brown for a 23-yard TD pass to make it 14-7.
After two consecutive three-and-out series, Brady led the Bucs on another scoring drive with Fournette running in from the 2 to extend the lead to 21-7. Tampa increased its lead to 28-7 when Fournette walked in from the 1 in the third quarter.
Brady was 19 of 22 before missing three consecutive passes late in the second quarter, including a deep ball intercepted by Anthony Harris that ended his streak of 227 passes without a pick.
The Buccaneers were already missing cornerbacks Carlton Davis and Sean Murphy-Bunting before Sherman went down on Philadelphia's first drive.
Still, Hurts struggled throwing the ball. He was 12 of 26 for 155 yards, one TD and one interception. Hurts ran for 44 yards and two scores.
![Tampa Bay Buccaneers quarterback Tom Brady (12) looks to pass during the first half of an NFL football game against the Philadelphia Eagles on Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Slocum)]()
Tampa Bay Buccaneers quarterback Tom Brady (12) looks to pass during the first half of an NFL football game against the Philadelphia Eagles on Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Slocum)
![Tampa Bay Buccaneers wide receiver Antonio Brown (81) scores a touchdown during the first half of an NFL football game against the Philadelphia Eagles on Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Rourke)]()
Tampa Bay Buccaneers wide receiver Antonio Brown (81) scores a touchdown during the first half of an NFL football game against the Philadelphia Eagles on Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Rourke)
![Philadelphia Eagles quarterback Jalen Hurts (1) celebrates his touchdown with Philadelphia Eagles tight end Zach Ertz (86) during the second half of an NFL football game against the Tampa Bay Buccaneers on Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Rourke)]()
Philadelphia Eagles quarterback Jalen Hurts (1) celebrates his touchdown with Philadelphia Eagles tight end Zach Ertz (86) during the second half of an NFL football game against the Tampa Bay Buccaneers on Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Rourke)
![Philadelphia Eagles quarterback Jalen Hurts scores a touchdown during the second half of an NFL football game against the Tampa Bay Buccaneers on Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Slocum)]()
Philadelphia Eagles quarterback Jalen Hurts scores a touchdown during the second half of an NFL football game against the Tampa Bay Buccaneers on Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Slocum)
![Philadelphia Eagles wide receiver DeVonta Smith (6) runs with the ball past Tampa Bay Buccaneers Ross Cockrell, bottom, Mike Edwards, right, and Jordan Whitehead during the second half of an NFL football game Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Rourke)]()
Philadelphia Eagles wide receiver DeVonta Smith (6) runs with the ball past Tampa Bay Buccaneers Ross Cockrell, bottom, Mike Edwards, right, and Jordan Whitehead during the second half of an NFL football game Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Rourke)
![Tampa Bay Buccaneers tight end O.J. Howard (80) is stopped by Philadelphia Eagles outside linebacker Genard Avery (58) during the second half of an NFL football game Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Slocum)]()
Tampa Bay Buccaneers tight end O.J. Howard (80) is stopped by Philadelphia Eagles outside linebacker Genard Avery (58) during the second half of an NFL football game Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Slocum)
![Tampa Bay Buccaneers head coach Bruce Arians claps during the first half of an NFL football game against the Philadelphia Eagles on Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Slocum)]()
Tampa Bay Buccaneers head coach Bruce Arians claps during the first half of an NFL football game against the Philadelphia Eagles on Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Slocum)
![Philadelphia Eagles quarterback Jalen Hurts (1) scores a touchdown in front of Tampa Bay Buccaneers defensive back Dee Delaney (30) during the second half of an NFL football game Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Slocum)]()
Philadelphia Eagles quarterback Jalen Hurts (1) scores a touchdown in front of Tampa Bay Buccaneers defensive back Dee Delaney (30) during the second half of an NFL football game Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Slocum)
![Philadelphia Eagles free safety Anthony Harris (28) stops Tampa Bay Buccaneers running back Leonard Fournette (7) during the second half of an NFL football game Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Slocum)]()
Philadelphia Eagles free safety Anthony Harris (28) stops Tampa Bay Buccaneers running back Leonard Fournette (7) during the second half of an NFL football game Thursday, Oct. 14, 2021, in Philadelphia. (AP Photo/Matt Slocum)
