CHAMPAIGN, Ill. -- Chase Brown scored three touchdowns and rushed for 151 yards and Tommy DeVito completed 27 of 37 passes for 192 yards and two scores in his debut as Illinois breezed past Wyoming 38-6 in a season-opener on Saturday.
Only 41 seconds elapsed before Brown found his way into the end zone, latching on to a 14-yard pass from DeVito to put Illinois in front.
"I thought Tommy really showed great composure," Illinois Coach Bret Bielema said. "He's a very accurate passer. He had some glitches today, but things we can definitely clean up."
Brown surpassed 2,000 career rushing yards -- including his freshman season at Western Michigan -- on an 18-yard run in the second quarter. Brown followed with an 11-yard TD run and kicker Caleb Griffin connected from 27 yards out to give Illinois a 17-3 halftime lead.
"A lot of times, running backs jump the gun on their keys and their reads, and he's just really patient and I think playing at a high level," said Bielema, the former University of Arkansas coach.
Brown is the 19th Illinois running back to hit the 2,000-yard career mark.
"We've got to be better going into Big Ten play to really make a statement," Brown said. "We did what we were supposed to today. We all knew that we would win this game, but it's going in there next week against Indiana where we can really make a statement."
Wyoming quarterback Andrew Peasley completed just 6 of 21 passes for 40 yards in his debut.
Cowboys running back Titus Swen rushed for 98 yards on 17 carries, while Peasley added 76 rushing yards on eight attempts.
"Our guys are trying. We just didn't play very well and we didn't coach very well," Wyoming Coach Craig Bohl said.
Swen left the game with what Bohl said could be a rib injury after a 6-yard run in the fourth.
The Cowboys converted just 1 of 12 third-down attempts, while the Illini were successful on 7 of 16.
John Hoyland had field goals of 22 and 46 yards for the Cowboys.
"It's hard right now, but I do know this, we've got a lot of resolve in the locker room," Bohl said. "(We have) coaches that want to work hard, and we're going to come back. But yeah, it's real frustrating."
Illinois increased its lead to 31-6 early in the fourth quarter when Brown scored on a 5-yard run. Reggie Love tacked on late score with a 33-yard rush after he narrowly stayed on his feet and avoided the sideline.
DeVito, who transferred to Illinois from Syracuse, said he had enough time in the pocket to sift through his third and fourth options on certain passing downs.
"I'm not taking any shots here, but I think this is the first game that I've been in where I did not get sacked," DeVito said. "Am I fair to say that?"
Sixth-year offensive tackle Alex Palczewski made his program record 53rd career start to break a tie with former teammate and current Minnesota Vikings tackle Vederian Lowe.
First-year offensive coordinator Barry Lunney Jr. (Fort Smith) sped up the tempo at times, regularly going no-huddle in a bid to wear down Wyoming's defensive front.
"We're a no-huddle team now, there's a lot of things that go into that," Bielema said. "Barry is just extremely gifted in the way he thinks and communicates with our players. I think that definitely showed up today with the number of guys that played."
Illinois running back Chase Brown (2) carries the ball during the first half of an NCAA college football game against Wyoming, Saturday, Aug. 27, 2022, in Champaign, Ill. (AP Photo/Charles Rex Arbogast)
Illinois quarterback Tommy DeVito passes during the first half of an NCAA college football game against Wyoming, Saturday, Aug. 27, 2022, in Champaign, Ill. (AP Photo/Charles Rex Arbogast)
Illinois quarterback Tommy DeVito passes during the first half of an NCAA college football game against Wyoming, Saturday, Aug. 27, 2022, in Champaign, Ill. (AP Photo/Charles Rex Arbogast)
Illinois quarterback Tommy DeVito hands off to running back Chase Brown during the first half of an NCAA college football game against Wyoming, Saturday, Aug. 27, 2022, in Champaign, Ill. (AP Photo/Charles Rex Arbogast)
Illinois running back Chase Brown scores his second touchdown of the game during the first half of an NCAA college football game against Wyoming, Saturday, Aug. 27, 2022, in Champaign, Ill. (AP Photo/Charles Rex Arbogast)
Wyoming quarterback Andrew Peasley fakes a hand off during the first half of an NCAA college football game against Illinois, Saturday, Aug. 27, 2022, in Champaign, Ill. (AP Photo/Charles Rex Arbogast)
Illinois running back Chase Brown (2) carries the ball during the first half of an NCAA college football game against Wyoming, Saturday, Aug. 27, 2022, in Champaign, Ill. (AP Photo/Charles Rex Arbogast)
Wyoming head coach Craig Bohl, left, and Illinois head coach Brent Bielema talk after Illinois defeated Wyoming in an NCAA college football game Saturday, Aug. 27, 2022, in Champaign, Ill. (AP Photo/Charles Rex Arbogast)
Wyoming quarterback Andrew Peasley walks off the field after his team's loss to Illinois in an NCAA college football game Saturday, Aug. 27, 2022, in Champaign, Ill. (AP Photo/Charles Rex Arbogast)