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story.lead_photo.caption In this Tuesday, May 23, 2017 file photo, activists dressed as characters from "The Handmaid's Tale", chant in the Texas Capitol Rotunda as they protest SB8, a bill that would require health care facilities, including hospitals and abortion clinics, to bury or cremate any fetal remains whether from abortion, miscarriage or stillbirth, and they would be banned from donating aborted fetal tissue to medical researchers in Austin. Tissue left over from elective abortions has been used in scientific research for decades, and is credited with leading to lifesaving vaccines and other advances. (AP Photo/Eric Gay)

WASHINGTON -- To save babies from brain-damaging birth defects, University of Pittsburgh scientist Carolyn Coyne studies placentas from fetuses that otherwise would be discarded -- and she's worried this kind of research is headed for the chopping block.

President Donald Trump's administration is cracking down on fetal-tissue research, with new hurdles for government-funded scientists around the country who call the special cells vital for fighting a variety of health threats. Already, the administration has shut down one university's work using fetal tissue to test HIV treatments and is ending other fetal-tissue research at the National Institutes of Health.

"I knew this was something that's going to trickle down to the rest of us," said Coyne. She uses the placenta, which people may not think of as fetal tissue but technically is classified as such because the fetus produced it, to study how viruses such as Zika get past that protective barrier early in pregnancy.

"It seems to me what we're moving toward is a ban," she added. If so, when it comes to unraveling what happens in pregnancy and fetal development, "we're going to stay ignorant to a lot of things," she said.

Different types of tissue left over from elective abortions have been used in scientific research for decades, and the work has been credited with leading to lifesaving vaccines and other advances. Under orders from Trump, the Health and Human Services Department on Wednesday announced the new restrictions that apply to taxpayer-funded research but not privately funded work.

Aside from the cancellation of an HIV-related project at the University of California, San Francisco, university-led projects that are funded by the National Institutes of Health -- estimated to be fewer than 200 -- aren't affected right away.

But the Health and Human Services Department said that as researchers seek to renew their funding or propose new studies, they will have to pass an extra layer of review, beyond today's strict scientific scrutiny. Each project will have a federal ethics board appointed to recommend whether the National Institutes of Health should grant the money.

The Health and Human Services Department hasn't offered details, but under the law authorizing the review process, such an ethics board must include not only biomedical experts but also a theologian, and the nation's health secretary can overrule its advice.

"I predict over time we will see a slow and steady elimination of federal funding for research that uses fetal tissue, regardless of how necessary it is," said University of Wisconsin law professor Alta Charo, a nationally recognized bioethics expert.

Necessity is the crux of a fierce debate between abortion foes and scientists about whether there are alternatives to fetal tissue for research.

Zika offers a glimpse at the difficulty. Somehow, the Zika virus can sneak from the mother's bloodstream across the placenta, which protects and nourishes the fetus, and target the fetus's brain. It's something researchers hope to learn how to block.

Studying the placentas of small animals or even monkeys isn't a substitute because they differ from humans, said Emory University researcher Mehul Suthar. For example, the specific type of placental cell where Zika can lurk in humans isn't thought to be present in mouse placentas.

And because the placenta continually changes as the fetus that created it grows, first-trimester tissue may show a very different vulnerability than a placenta that's expelled during full-term birth, when it's no longer defined as fetal tissue but as medical waste.

Anti-abortion groups argue there are alternatives, such as using stem cells, growing organlike clumps of cells in lab dishes or using tissue taken from newborns as they have heart surgery.

Indeed, the National Institutes of Health is funding a $20 million program to research alternatives to fetal tissue and to prove whether they work as well.

"Taxpayer funding ought to go to promote alternatives that are already being used in the production of treatments, vaccines and medicines, and to expand approaches that do not depend on the destruction of unborn children," said Mallory Quigley of the Susan B. Anthony List, which works to elect anti-abortion candidates to public office.

But dozens of medical and science organizations have told the Health and Human Services Department that there is no substitute for fetal tissue in studying certain health issues, such as HIV, Zika, Alzheimer's, Parkinson's, spinal cord injury and a variety of eye diseases.

To Pittsburgh's Coyne, part of the political debate is a "completely unsubstantiated belief that not allowing research and science is going to prevent or stop abortions, which is not the case."

Medical research using fetal tissue won't stop but will move to other countries, said Charo, who advised President Barack Obama's administration. The United Kingdom, Australia, Singapore and China are among the countries using fetal tissue to seek breakthroughs.

"Other countries work with this in a regulated fashion, and they will continue to outstrip us," she said. "We have allowed patients' interests to become collateral damage in the abortion wars."

A Section on 06/09/2019

Print Headline: Fetal-tissue limits worry scientists


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  • WGT
    June 9, 2019 at 10 p.m.

    FFS. This country now is in the hold of theocracy. We have every opportunity to be the forefront of sciences and are squandering it on a bunch of ignorant fools who set their guidelines from a book of damn fairy tales.

  • Illinoisroy
    June 10, 2019 at 1 p.m.