Dixon Road is blocked west of Ironton Road after an 18-wheeler hit a ditch and spilled oil in the area, authorities said.
It happened before 6 a.m. and is expected to remain blocking the road for some time.
Police on the scene described the spill as asphalt oil the truck was carrying. Hazardous-material crews were called in to assist with the cleanup.
Police say the truck was attempting to turn around in a parking lot when its trailer clipped the ditch and turned onto its side.
No injuries were reported.